Novel naphthoquinones from a Streptomyces sp.

Authors
Kulanthaivel, P Perun, TJ Belvo, MD Strobel, RJ Paul, DC Williams, DC
Citation
P. Kulanthaivel et al., Novel naphthoquinones from a Streptomyces sp., J ANTIBIOT, 52(3), 1999, pp. 256-262
Citations number
8
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
52
Issue
3
Year of publication
1999
Pages
256 - 262
Database
ISI
SICI code
0021-8820(199903)52:3<256:NNFASS>2.0.ZU;2-R
Abstract
Cdc25A assay-guided fractionation of a fermentation broth derived from a St reptomyces sp. resulted in the isolation of four novel naphthoquinones 1 si milar to 4. Structures of these compounds were deduced by NMR and mass spec trometry. Two of them, 3 and 4, incorporate a modified cysteine residue whi ch is observed for the first time in this class of natural products. Naphth oquinones 1 similar to 4 showed weak activity against cdc25A phosphatase.