The bactericidal activities of HMR 3004, HMR 3647 and erythromycin againstGram-positive bacilli and development of resistance

Authors
Fernandez-Roblas, R Calvo, R Esteban, J Bryskier, A Soriano, F
Citation
R. Fernandez-roblas et al., The bactericidal activities of HMR 3004, HMR 3647 and erythromycin againstGram-positive bacilli and development of resistance, J ANTIMICRO, 43(2), 1999, pp. 285-289
Citations number
10
Categorie Soggetti
Pharmacology,Microbiology
Journal title
Journal of antimicrobial chemotherapy
ISSN journal
03057453 → ACNP
Volume
43
Issue
2
Year of publication
1999
Pages
285 - 289
Database
ISI
SICI code
Abstract
The bactericidal activities of two new ketolides, HMR 3004 and HMR 3647, an d the potential to develop resistance to these two antibiotics were studied in Gram-positive bacilli. As judged by time-kill kinetics both ketolides w ere mostly bacteriostatic, being bactericidal against only highly susceptib le isolates of Corynebacterium striatum (two isolates) and Corynebacterium minutissimum tone isolate). Spontaneous resistant mutants were detected in seven of 30 strains tested, mainly in Rhodococcus equi; C. minutissimum and C. striatum, with a very low frequency of mutation (10(-12)-10(-15)).