In-vitro bactericidal activity of cefpirome and cefamandole in combinationwith glycopeptides against methicillin-resistant Staphylococcus aureus

The bactericidal activity in vitro of cefpirome plus either vancomycin or t eicoplanin was compared with that of a cefamandole-vancomycin combination a gainst ten clinical isolates of homogeneous methicillin-resistant Staphyloc occus aureus. Cefpirome (0.125 x MIG) combined with vancomycin (0.5-2 x MIC ) or teicoplanin (0.5-4 x MIG) acted synergically against the ten isolates. Similar effects were observed with the cefamandole-vancomycin combination, except that for one isolate, higher cefamandole concentrations (0.25-1 x M IG) were required.