M. Pomeroy et M. Moriarty, CLINICAL-SIGNIFICANCE OF CELLULAR-RESISTANCE IN TUMORS TO CYTOTOXIC CHEMOTHERAPY AND RADIOTHERAPY, Cytotechnology, 12(1-3), 1993, pp. 385-391
Cellular resistance is a significant component of tumour treatment fai
lure. More detailed understanding of resistance mechanisms has enabled
us to plan circumvention strategies, though these are not yet in rout
ine clinical use. Such resistance is, however, only one of several fac
tors which render cure of advanced malignant disease difficult. It is
important for researchers in this field to see not only therapeutic op
portunities but also limitations of these approaches. It is hoped that
increased cooperation between clinicians and scientists in the field
of cellular resistance will yield further improvement in tumour respon
se rates and cure.