Langmuir-Blodgett films of antibodies as mediators of endothelial cell adhesion on polyurethanes

Authors
Ahluwalia, A Basta, G Ricci, D Francesconi, R Domenici, C Grattarola, M Palchetti, L Preininger, C De Rossi, D
Citation
A. Ahluwalia et al., Langmuir-Blodgett films of antibodies as mediators of endothelial cell adhesion on polyurethanes, J BIOM SC P, 10(3), 1999, pp. 295-304
Citations number
17
Categorie Soggetti
Multidisciplinary
Journal title
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
ISSN journal
09205063 → ACNP
Volume
10
Issue
3
Year of publication
1999
Pages
295 - 304
Database
ISI
SICI code
0920-5063(1999)10:3<295:LFOAAM>2.0.ZU;2-X
Abstract
The effect of endothelial cell adhesion on polyurethanes coated with Langmu ir-Blodgett antibody films has been examined. The films were cross-linked w ith glutaraldehyde with the aim of providing a densely packed and covalentl y linked two-dimensional antibody network on the polyurethane surfaces. Our results demonstrate that although,oh neither of the two polyurethanes exam ined were entirely suited to cellular adhesion, Langmuir-Blodgett antibody films, cross-linked with small concentrations of glutaraldehyde, are more s uitable for endothelial cell adhesion than surfaces free of antibody.