Tumour volume as a predictor of necrosis after chemotherapy in Ewing's sarcoma

Citation
A. Abudu et al., Tumour volume as a predictor of necrosis after chemotherapy in Ewing's sarcoma, J BONE-BR V, 81B(2), 1999, pp. 317-322
Citations number
25
Categorie Soggetti
Ortopedics, Rehabilitation & Sport Medicine","da verificare
Journal title
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME
ISSN journal
0301620X → ACNP
Volume
81B
Issue
2
Year of publication
1999
Pages
317 - 322
Database
ISI
SICI code
0301-620X(199903)81B:2<317:TVAAPO>2.0.ZU;2-C
Abstract
We studied the CT and MR scans, and the histology of 50 patients with prima ry Ewing's sarcoma of bone to determine the association between the change in tumour volume and necrosis after chemotherapy, and to ascertain their in fluence on prognosis, The mean age of the patients was 17 years. The limbs were involved in 40 and the axial bones in ten. The volume of the tumour at diagnosis varied from 31 to 1790 ml, There was a significant relationship between necrosis and the measured chan ge in volume of the tumour after chemotherapy. Progression of the tumour de spite chemotherapy was seen only in patients with necrosis of grades 4 to 6 . Necrosis significantly influenced survival (p < 0.05), but the effect of change in volume was less significant. Change in volume of the tumour is a good predictor of necrosis induced by c hemotherapy, Necrosis is a strong prognostic factor in Ewing's sarcoma.