RESOLVING AGENTS .1. (R)-(-)-2-AMINO-1-BENZYLOXYBUTANE, A NEW BASE FOR THE RESOLUTION OF RACEMIC ACIDS

Authors
TOUET J RUAULT T BROWN E
Citation
J. Touet et al., RESOLVING AGENTS .1. (R)-(-)-2-AMINO-1-BENZYLOXYBUTANE, A NEW BASE FOR THE RESOLUTION OF RACEMIC ACIDS, Synthetic communications, 24(3), 1994, pp. 293-300
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
24
Issue
3
Year of publication
1994
Pages
293 - 300
Database
ISI
SICI code
0039-7911(1994)24:3<293:RA.(AN>2.0.ZU;2-Y
Abstract
Treatment of the readily available (R)-(-) enantiomer of 2-aminobutan- 1-ol 1 with sodium hydride followed by benzyl chloride afforded the ($ ) under bar O-benzyl base (R)-(-)-2. The latter was successfully used for the resolution of racemic alpha-methylsuccinic and alpha-bromosucc inic acids, as well as of the racemic alpha-benzylhemisuccinic esters 8 and 9 respectively.