CELL-KINETICS AND TOOTH CYTODIFFERENTIATI ONS

Several experimental results led to the hypothesis that odontoblast's and ameloblast's genetic programmes may determine a minimal number of cell cycles before overt differentiation can be triggered by specific, epigenetic, matrix-mediated interactions. The cell kinetic dependent maturation of the dental cells could imply transcriptional modificatio ns of matrix molecules and paracrine factors involved in the control o f the respective cytodifferentiations and of specific receptors confer ing competence to the responding cells.