Ak. Sadhukhan et al., Optimization of mycophenolic acid production in solid state fermentation using response surface methodology, J IND MIC B, 22(1), 1999, pp. 33-38
Citations number
27
Categorie Soggetti
Biotecnology & Applied Microbiology
Journal title
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
Mycophenolic acid (MPA) can be produced in solid state fermentation, An iso
late of Penicillium brevi-compactum ATCC 16024 grown on moist wheat bran pr
oduced a titre of 425 mg per kg of wheat bran. Central composite rotatable
design and response surface methodology were employed to derive a statistic
al model for media optimization towards production of mycophenolic acid, Fi
ve levels with a five factorial design were adopted. The correlation coeffi
cient was 0.82, ensuring a satisfactory adjustment of the model to the expe
rimental values. This statistical design was Very effective in improving th
e titre of mycophenolic acid up to 3286 mg per kg of wheat bran.