Citation
Yh. Deng et al., Remangilones A-C, new cytotoxic triterpenes from Physena madagascariensis, J NAT PROD, 62(3), 1999, pp. 471-476
Citations number
23
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864
→ ACNP
Volume
62
Issue
3
Year of publication
1999
Pages
471 - 476
Database
ISI
SICI code
0163-3864(199903)62:3<471:RANCTF>2.0.ZU;2-T
Abstract
Three new 24,28-dinorolean-3-one derivatives, the remangilones A-C (1-3), w
ere isolated from the dried leaves of Physena madagascariensis using a huma
n mammary carcinoma cell line to guide the isolation. The structures of 1-3
were deduced primarily from NMR studies. Compounds 1 and 3, remangilones A
and C, respectively, were found to be cytotoxic against two human breast c
ancer cell lines and induced apoptosis at concentrations of 2.3 mu M.