LIPOSOME-ENTRAPPED PGE(1) POSTTREATMENT DECREASES IL-1-ALPHA-INDUCED NEUTROPHIL ACCUMULATION AND LUNG LEAK IN RATS

Citation
Ja. Leff et al., LIPOSOME-ENTRAPPED PGE(1) POSTTREATMENT DECREASES IL-1-ALPHA-INDUCED NEUTROPHIL ACCUMULATION AND LUNG LEAK IN RATS, Journal of applied physiology, 76(1), 1994, pp. 151-157
Citations number
31
Categorie Soggetti
Physiology
ISSN journal
87507587
Volume
76
Issue
1
Year of publication
1994
Pages
151 - 157
Database
ISI
SICI code
8750-7587(1994)76:1<151:LPPDIN>2.0.ZU;2-3
Abstract
We found that treatment with liposome-entrapped prostaglandin E(1) (Li p-PGE(1)), but not with empty liposomes and/or free PGE(1), decreased the leak of intravascularly administered I-125-labeled albumin into lu ngs of rats given interleukin-1 alpha (IL-1 alpha) intratracheally. Li p-PGE(1) treatment also decreased lung myeloperoxidase activity, lung lavage neutrophil increases, and lung histological abnormalities found in rats given IL-1 alpha intratracheally. Interestingly, decreased lu ng leak and lung neutrophil accumulation occurred when Lip-PGE(1) was given intravenously 2.5 h after, but not immediately before, intratrac heal IL-1 alpha administration. When Lip-PGE(1) treatment was given bo th before and 2.5 h after IL-1 alpha administration, lung leak was dec reased to baseline levels. Lip-PGE(1) treatment given 2.5 h after IL-1 alpha administration also decreased lung oxidized glutathione levels, which increased in rats given IL-1 alpha intratracheally. We conclude that postinsult treatment with Lip-PGE(1) decreases lung leak, neutro phil recruitment, and oxidative responses in lungs of rats given IL-1 alpha intratracheally.