Ja. Leff et al., LIPOSOME-ENTRAPPED PGE(1) POSTTREATMENT DECREASES IL-1-ALPHA-INDUCED NEUTROPHIL ACCUMULATION AND LUNG LEAK IN RATS, Journal of applied physiology, 76(1), 1994, pp. 151-157
We found that treatment with liposome-entrapped prostaglandin E(1) (Li
p-PGE(1)), but not with empty liposomes and/or free PGE(1), decreased
the leak of intravascularly administered I-125-labeled albumin into lu
ngs of rats given interleukin-1 alpha (IL-1 alpha) intratracheally. Li
p-PGE(1) treatment also decreased lung myeloperoxidase activity, lung
lavage neutrophil increases, and lung histological abnormalities found
in rats given IL-1 alpha intratracheally. Interestingly, decreased lu
ng leak and lung neutrophil accumulation occurred when Lip-PGE(1) was
given intravenously 2.5 h after, but not immediately before, intratrac
heal IL-1 alpha administration. When Lip-PGE(1) treatment was given bo
th before and 2.5 h after IL-1 alpha administration, lung leak was dec
reased to baseline levels. Lip-PGE(1) treatment given 2.5 h after IL-1
alpha administration also decreased lung oxidized glutathione levels,
which increased in rats given IL-1 alpha intratracheally. We conclude
that postinsult treatment with Lip-PGE(1) decreases lung leak, neutro
phil recruitment, and oxidative responses in lungs of rats given IL-1
alpha intratracheally.