Vitamin E is considered to be one of the most important antioxidants, There
is a trend today to supply diabetic children with vitamin E in order to pr
event microvascular complications. In this study, our objective was to demo
nstrate validity of plasma and erythrocyte vitamin E levels in diabetic chi
ldren. This study was conducted on twenty-five diabetic patients aged from
7-16 years and ten non-diabetic, age-matched healthy subjects as the contro
l group. Vitamin E levels were measured by high-performance liquid chromato
graphy. There was no significant difference between the mean plasma vitamin
E levels of diabetic and control groups, 870.80 +/- 220.51 mu g/dl and 891
+/- 221.21 mu g/dl, respectively (p>0.05), The mean erythrocyte vitamin E
levels of diabetic and control groups were significantly different: 183.12
+/- 62.58 mu g/dl and 246.90 +/- 68.26 mu g/dl, respectively (p<0.05). Eryt
hrocyte vitamin E levels were significantly lower than plasma vitamin E lev
els in both groups. We further investigated whether a correlation exists be
tween plasma and erythrocyte vitamin E levels and duration of diabetes, ins
ulin dose and HbA(1c) measurements. However no correlation was found. In co
nclusion, measurement of erythrocyte vitamin E levels may be considered to
be more valuable than plasma vitamin E levels in diabetic children and supp
lementation may be provided according to erythrocyte levels rather than pla
sma levels.