NEW 2-ALKYLIDENEMETHYL-5-NITROTHIOPHENES - PREPARATION VIA S(RN)1 REACTIONS AND IN-VITRO ANTIPROTOZOAN ACTIVITY

Authors
VANELLE P GHEZALI S MALDONADO J CROZET MP DELMAS F GASQUET M TIMONDAVID P
Citation
P. Vanelle et al., NEW 2-ALKYLIDENEMETHYL-5-NITROTHIOPHENES - PREPARATION VIA S(RN)1 REACTIONS AND IN-VITRO ANTIPROTOZOAN ACTIVITY, European journal of medicinal chemistry, 29(1), 1994, pp. 41-44
Citations number
22
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
29
Issue
1
Year of publication
1994
Pages
41 - 44
Database
ISI
SICI code
0223-5234(1994)29:1<41:N2-PVS>2.0.ZU;2-G
Abstract
The reaction of 2-chloromethyl-5-nitrothiophene with the 2-nitropropan e anion has been reinvestigated and extended to various nitronate anio ns to afford good yields of new 5-nitrothiophenes bearing a trisubstit uted ethylenic double bond at the 2-position. These compounds were eva luated as potential antiprotozoan agents and some derivatives were fou nd to have the same activity as that of reference compounds.