Sweetener augmentation of serum triacylglycerol during a fat challenge test in humans

Objective: High concentrations of fructose enhance postprandial lipemia fol lowing lipid loading whereas glucose exerts a negative or minimal effect. T his study evaluated the effect of lower sweetener concentrations and the co ntribution of their sweetness level and palatability. Methods: At each of four test sessions, twelve male and ten female healthy adults ingested one of four milkshakes containing 108 g dairy cream alone o r supplemented with 30 g fructose, 17.5 g glucose or 1 g aspartame. Blood s amples were collected at baseline, two, four, six and eight hours after ing estion. Sensory discrimination tests were conducted after the last two sess ions. Results: Fructose and glucose led to 37% (p=0.03) and 59% (p=0.08) rises in triacylglycerol area under the curve (TG AUG) when compared to the plain m ilkshake, respectively. Although the sweetened shakes were equisweet and we re more palatable than the plain shake, the TG rise after the aspartame mil kshake did not differ from the plain milkshake. Conclusions: These data indicate that low levels of glucose and fructose co nsumed with lipid enhance postprandial lipemia. Sweetness and palatability did not account for the effect.