Detection of antibodies against hepatitis C virus in saliva: a marker of viral replication

Citation
So. Cameron et al., Detection of antibodies against hepatitis C virus in saliva: a marker of viral replication, J VIRAL HEP, 6(2), 1999, pp. 141-144
Citations number
11
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
JOURNAL OF VIRAL HEPATITIS
ISSN journal
13520504 → ACNP
Volume
6
Issue
2
Year of publication
1999
Pages
141 - 144
Database
ISI
SICI code
1352-0504(199903)6:2<141:DOAAHC>2.0.ZU;2-P
Abstract
Hepatitis C surveillance has been restricted owing to the lack of a sensiti ve antibody assay for saliva. The aim of our study was to develop and evalu ate a screening assay for hepatitis C antibody in saliva specimens. Serum/s aliva pairs were collected from 115 hepatitis C-positive patients. A modifi ed hepatitis C antibody assay for saliva was developed and linked to testin g carried out in the diagnostic laboratory. Correlation between the presenc e of antibody in serum and in saliva was poor (100% vs 85%). However, of 98 patients who were saliva antibody positive, 96 (98%) were also serum hepat itis C RNA positive and two (2%) were serum hepatitis C RNA negative. Hence , the correlation between a positive salivary antibody test and the serum h epatitis C RNA status of intravenous drug users suggests that this test cou ld be used as a surrogate marker for hepatitis C viraemia in epidemiologica l studies.