Preconditioning: ischemia-induced tolerance to lethal injury

Authors
Citation
M. Ovize, Preconditioning: ischemia-induced tolerance to lethal injury, M S-MED SCI, 15(3), 1999, pp. 352-358
Citations number
47
Categorie Soggetti
Medical Research General Topics
Journal title
M S-MEDECINE SCIENCES
ISSN journal
07670974 → ACNP
Volume
15
Issue
3
Year of publication
1999
Pages
352 - 358
Database
ISI
SICI code
0767-0974(199903)15:3<352:PITTLI>2.0.ZU;2-G
Abstract
Repetition of one or several brief episodes of ischemia renders the myocard ium more resistant to a subsequent sustained coronary artery occlusion. The hallmark of tills phenomenon, termed preconditioning, is infarct size limi tation. Its mechanism is unclear but seems to involve the release of severa l mediators, including adenosine, norepinephrine, bradykinin, endothelin-1 and the activation of protein kinase C. This cardioprotection is not limite d to the heart but can affect many other organs. Recent evidence suggests t hat it may also apply to the human heart, especially during cardiac surgery , coronary angioplasty or in the clinical settings of pre-infarction angina .