Evaluation of two methods to avoid contrast associated nephropathy.

Our objective was to establish the efficacy of two methods to avoid contras t associated nephropathy (C.A.N). We studied in prospective and randomized form a sample of 75 patients of whom 25 were assigned to the Control group: without interventions; 25 to the Saline group: 0.45% saline solution I.V., 1.5 cc/kg/min, 6 hours before and after the angiographic study and 25 to t he Dopa group: equal procedure plus the aggregate of dopamine 2 mu g/kg/min , 30 minutes before the study until the termination. The evaluation effecte d at patient's entry was considered T0, T1, 24 hs after and T2, 48 hs after . In T0 was registered: age, sex, pathological antecedents, drugs and plasm atic creatinine, and in T2 creatinine. An increase of 25% of the plasmatic creatinine in T2 was considered as C.A.N. The latter was present in 13/25 ( OR: 1) Control group patients, 7/25 (OR 0.36), Salina group patients and in 5/25 (OR 0.23) Dopa group patients (p = 0.11). No significant difference w as registered in the urinary output nor in the plasmatic creatinine levers. It is concluded that hydration during six hours before and after the study with 0.45% saline solution and the same plan with the aggregate of dopamin e are effective to prevent a C.A.N.