Highly diastereoselective one-pot four-component coupling of p-TolSCl, 1-methoxycycloalkene, methyl vinyl ether and a carbon nucleophile leading to the synthesis of polyfunctional compounds

An one-pot TiCl4 initiated assemblage of polyfunctional compounds via a seq uential coupling of p-TolSCl, 1-methoxycycloalkene, methyl vinyl ether and Sn- or Si-capped carbon nucleophile is shown to proceed with high diastereo selectivity at all newly created chiral centres.