Preproenkephalin mRNA and enkephalin levels in the adult Syrian hamster: the influence from glucocorticoids

Authors
Jimenez, R Yoburn, BC Calvano, SE Franklin, SO
Citation
R. Jimenez et al., Preproenkephalin mRNA and enkephalin levels in the adult Syrian hamster: the influence from glucocorticoids, MOL BRAIN R, 66(1-2), 1999, pp. 179-183
Citations number
34
Categorie Soggetti
Neurosciences & Behavoir
Journal title
MOLECULAR BRAIN RESEARCH
ISSN journal
0169328X → ACNP
Volume
66
Issue
1-2
Year of publication
1999
Pages
179 - 183
Database
ISI
SICI code
0169-328X(19990320)66:1-2<179:PMAELI>2.0.ZU;2-K
Abstract
Proenkephalin (Penk) gene structure in hamsters and humans are similar but they differ from rats. Ln this study hamster Penk gene expression was exami ned after hypophysectomy +/- glucocorticoid receptor blockade with RU 486 ( mifepristone). Zn contrast to rats, basal Penk gene expression in hamster a drenals did not change after treatments that reduced both the influence fro m glucocorticoids and phenylethanolamine-N-methyltransferase mRNA levels. M eanwhile, striatal preproenkephalin mRNA levels increased under these condi tions. (C) 1999 Elsevier Science B.V. All rights reserved.