Regional and cellular localization of calcitonin gene-related peptide-receptor component protein mRNA in the guinea-pig central nervous system

Authors
Oliver, KR Wainwright, A Kinsey, AM Heavens, RP Sirinathsinghji, DJS Hill, RG
Citation
Kr. Oliver et al., Regional and cellular localization of calcitonin gene-related peptide-receptor component protein mRNA in the guinea-pig central nervous system, MOL BRAIN R, 66(1-2), 1999, pp. 205-210
Citations number
21
Categorie Soggetti
Neurosciences & Behavoir
Journal title
MOLECULAR BRAIN RESEARCH
ISSN journal
0169328X → ACNP
Volume
66
Issue
1-2
Year of publication
1999
Pages
205 - 210
Database
ISI
SICI code
0169-328X(19990320)66:1-2<205:RACLOC>2.0.ZU;2-X
Abstract
Recent cloning studies have isolated proteins which confer responsiveness t o calcitonin gene-related peptide (CGRP). In this study, we have determined the central nervous system (CNS) distribution of the mRNA of one such prot ein, termed CGRP-receptor component protein (RCP), by in situ hybridization . CGRP-RCP mRNA was widely expressed in the guinea-pig CNS, being particula rly abundant in cerebellum and hippocampus. These data should assist in the determination of the potential physiological function(s) of this protein i n the CNS. (C) 1999 Elsevier Science B.V. All rights reserved.