Neuropeptide Y: a key molecule in anorexia and cachexia in wasting disorders?

Authors
Inui, A
Citation
A. Inui, Neuropeptide Y: a key molecule in anorexia and cachexia in wasting disorders?, MOL MED TOD, 5(2), 1999, pp. 79-85
Citations number
44
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
MOLECULAR MEDICINE TODAY
ISSN journal
13574310 → ACNP
Volume
5
Issue
2
Year of publication
1999
Pages
79 - 85
Database
ISI
SICI code
1357-4310(199902)5:2<79:NYAKMI>2.0.ZU;2-M
Abstract
Anorexia and body weight loss are characteristic of many diseases, includin g cancer and AIDS. Recent studies indicate that inflammatory cytokines, suc h as interleukin 1, the interleukin 6 subfamily and tumor necrosis factor, induce anorexia and cachexia by inhibiting the normal adaptive feeding resp onse to energy deficits. Here, I discuss the evidence for and against a cen tral role for neuropeptide Y and leptin in anorexia and cachexia.