3-(2-alkylsulfanyl-6-benzothiazolylaminomethyl)-2-benzoxazolethiones - Synthesis and photosynthesis-inhibiting activity in spinach chloroplasts

The synthesis and photosynthesis-inhibiting activity of 14 new 3-(2-alkylsu lfanyl-6-benzothiazolylaminomethyl)-2-benzoxazolethiones are reported. The new compounds were prepared by the reaction of 2-alkylsulfanyl-6-aminobenzo thiazoles with 3-hydroxymethyl-2-benzoxazolethione. The structures of the c ompounds were verified by H-1 NMR spectra. The compounds inhibit photosynth etic electron transport in spinach chloroplasts. The photosynthetic activit y was found to depend on the calculated lipophilicity of the new compounds. Some structure characteristics and quantum chemical parameters were calcul ated by AM1 method.