Structural basis of Hox specificity

Authors
Wilson, DS Desplan, C
Citation
Ds. Wilson et C. Desplan, Structural basis of Hox specificity, NAT ST BIOL, 6(4), 1999, pp. 297-300
Citations number
35
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NATURE STRUCTURAL BIOLOGY
ISSN journal
10728368 → ACNP
Volume
6
Issue
4
Year of publication
1999
Pages
297 - 300
Database
ISI
SICI code
1072-8368(199904)6:4<297:SBOHS>2.0.ZU;2-Q
Abstract
On their own, the homeotic selector (Hox) transcriptional regulators bind v ery short, rather similar DNA sequences. To elevate their functional specif icity, Hox proteins heterodimerize with other homeodomain-containing protei ns. The structural basis for this fruitful partnership is now coming into v iew.