Treatment of dissociative symptoms in Borderline patients with Naltrexone

Dissociative symptoms including flashbacks, i.e. vivid scenic recollections of traumatic episodes, in patients with Borderline Personality Disorder ar e a serious and often treatment-refractory problem. There is evidence sugge sting changes in endogenous opioids in patients with Borderline Personality Disorder. Naltrexone, an opioid receptor antagonist, was administered to t hree female patients with Borderline Personality Disorder in a dosage of 50 mg (q.i.d., p.o.) over several weeks. We observed a marked reduction in di ssociative symptoms.