5-HT4 receptor modulation of acetylcholine outflow in guinea pig brain slices

Citation
A. Siniscalchi et al., 5-HT4 receptor modulation of acetylcholine outflow in guinea pig brain slices, NEUROREPORT, 10(3), 1999, pp. 547-551
Citations number
23
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
09594965 → ACNP
Volume
10
Issue
3
Year of publication
1999
Pages
547 - 551
Database
ISI
SICI code
0959-4965(19990225)10:3<547:5RMOAO>2.0.ZU;2-R
Abstract
THE effect of the 5-HT4 agonist, BIMU-8 was studied on [(3)]choline outflow in guinea pig brain slices and synaptosomes. BIMU-8 did not modify [(3)]ch oline efflux in slices kept at rest, but increased [H-3]choline outflow in electrically stimulated slices of cerebral cortex (CC), hippocampus (hip) a nd nucleus basalis magnocellularis (nbm). This effect was prevented by the selective 5-HT4 antagonist, GR 125487. Conversely, BIMU-8 did not affect [H -3]choline efflux in hippocampal synaptosomes depolarized with KCI 20mM. Th ese results provide evidence that BIMU-8 increases the electrically trigger ed [H-3]choline efflux in CC, hip and nbm slices. A possible role of 5-HT4 agonists in memory and learning diseases is suggested. (C) 1999 Lippincott Williams & Wilkins.