Simultaneous monitoring of endothelin-1 and vasopressin plasma levels in migraine

VASOPRESSIN levels in plasma rise during migraine attacks. Vasopressin also induces endothelin-l synthesis in endothelial cells, suggesting a role as a mediator of elevated plasma endothelin-l in migraine. To explore a possib le relationship betwen endothelin-l and vasopressin in migraine, plasma con centrations of both peptides were monitored simultaneously throughout an at tack and during two migraine-free intervals (control) in 20 patients. Endot helin-1 was elevated 6 h after the onset of an attack (3.3 +/- 0.3 pg/ml us 2.7 +/- 0.2pg/ml during migraine-free intervals; p = 0.12) whereas vasopre ssin was increased over control levels (2.8 +/- 0.3 pg/ml) by 3 h (3.6 +/- 0.4 pg/ml; p < 0.05) and remained elevated at 6 h (3.9 +/- 0.5 pg/ml; p < 0 .01). These data suggest that vasopressin may act as a peripheral mediator of increased plasma endothelin-l in migraine. (C) 1999 Lippincott Williams & Wilkins.