R. Dantzer et al., Central administration of insulin-like growth factor-1 inhibits lipopolysaccharide-induced sickness behavior in mice, NEUROREPORT, 10(2), 1999, pp. 289-292
To assess the possible modulatory effects of insulin-like growth factor-1 (
IGF-1) on the brain effects of proinflammatory cytokines, male CD-1 mice we
re injected into the lateral ventricle of the brain with a behaviorally dep
ressing dose (100 ng) of the cytokine inducer lipopolysaccharide (LPS) and
their response to various doses of IGF-1 (0, 100 and 1000 ng) was measured
during behavioral tests carried before and at various time intervals after
treatment. LPS induced a profound behavioral depression that was abrogated
by the higher dose of IGF-1 tested. Since the behavioral effects of LPS are
mediated by the local synthesis and results of proinflammatory cytokines,
these results indicate that IGF-1 interferes with the production and/or act
ion of proinflammatory cytokines in the brain. (C) 1999 Lippincott Williams
& Wilkins.