Central administration of insulin-like growth factor-1 inhibits lipopolysaccharide-induced sickness behavior in mice

Citation
R. Dantzer et al., Central administration of insulin-like growth factor-1 inhibits lipopolysaccharide-induced sickness behavior in mice, NEUROREPORT, 10(2), 1999, pp. 289-292
Citations number
25
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
09594965 → ACNP
Volume
10
Issue
2
Year of publication
1999
Pages
289 - 292
Database
ISI
SICI code
0959-4965(19990205)10:2<289:CAOIGF>2.0.ZU;2-Q
Abstract
To assess the possible modulatory effects of insulin-like growth factor-1 ( IGF-1) on the brain effects of proinflammatory cytokines, male CD-1 mice we re injected into the lateral ventricle of the brain with a behaviorally dep ressing dose (100 ng) of the cytokine inducer lipopolysaccharide (LPS) and their response to various doses of IGF-1 (0, 100 and 1000 ng) was measured during behavioral tests carried before and at various time intervals after treatment. LPS induced a profound behavioral depression that was abrogated by the higher dose of IGF-1 tested. Since the behavioral effects of LPS are mediated by the local synthesis and results of proinflammatory cytokines, these results indicate that IGF-1 interferes with the production and/or act ion of proinflammatory cytokines in the brain. (C) 1999 Lippincott Williams & Wilkins.