Sphingosylphosphorylcholine increases calcium concentration in isolated brain nuclei

Authors
Calcerrada, MC Miguel, BG Catalan, RE Martinez, AM
Citation
Mc. Calcerrada et al., Sphingosylphosphorylcholine increases calcium concentration in isolated brain nuclei, NEUROSCI RE, 33(3), 1999, pp. 229-232
Citations number
22
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE RESEARCH
ISSN journal
01680102 → ACNP
Volume
33
Issue
3
Year of publication
1999
Pages
229 - 232
Database
ISI
SICI code
0168-0102(199903)33:3<229:SICCII>2.0.ZU;2-I
Abstract
Sphingosylphosphorylcholine (SPC) caused a rapid increase of Ca2+ concentra tion in isolated brain nuclei. This effect was prevented by nimodipine, an inhibitor of L-type Ca2+ channels, and by thapsigargin, an inhibitor of Ca2 +-ATPase. Neither heparin nor U73122 modified this effect, suggesting that phospholipase C activation and inositol 1,4,5-trisphosphate (IP3) productio n are not involved. Results also indicated that SPC-induced increase in Ca2 + concentration is not protein kinase C-dependent. (C) 1999 Elsevier Scienc e Ireland Ltd. All rights reserved.