Towards mixed sequence recognition by triple helix formation

The formation of intermolecular DNA triple helices offers the possibility o f designing compounds with extensive sequence recognition properties which may be useful as antigene agents or tools in molecular biology. One major l imitation of this approach is that these structures are generally restricte d to homopurine homopyrimidine target sites. This review describes the stra tegies that have been employed to overcome this drawback and outlines the p otential for tripler formation at mixed sequence DNA targets.