A concise two-step synthesis of thalidomide

Authors
Muller, GW Konnecke, WE Smith, AM Khetani, VD
Citation
Gw. Muller et al., A concise two-step synthesis of thalidomide, ORG PROC R, 3(2), 1999, pp. 139-140
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC PROCESS RESEARCH & DEVELOPMENT
ISSN journal
10836160 → ACNP
Volume
3
Issue
2
Year of publication
1999
Pages
139 - 140
Database
ISI
SICI code
1083-6160(199903/04)3:2<139:ACTSOT>2.0.ZU;2-C
Abstract
A two-step synthesis of thalidomide is presented. The sequence requires no purifications. Treatment of L-glutamine with N-carbethoxyphthalimide produc es N-phthaloyl-L-glutamine. Cyclization of N-phthaloyl-L-glutamine to affor d thalidomide is accomplished by treatment with CDI in the presence of a ca talytic amount of DMAP.