Granulocyte colony-stimulating factor and drugs elevating extracellular adenosine act additively to enhance the hemopoietic spleen colony formation in irradiated mice
M. Hofer et al., Granulocyte colony-stimulating factor and drugs elevating extracellular adenosine act additively to enhance the hemopoietic spleen colony formation in irradiated mice, PHYSL RES, 48(1), 1999, pp. 37-42
The effects of combined administration of two drugs elevating extracellular
adenosine, namely dipyridamole (DP) and adenosine monophosphate (AMP), and
granulocyte colony-stimulating factor (G-CSF) on hemopoietic stem cells in
vivo were investigated. The experiments were performed on mice using the e
ndogenous spleen colony formation in gamma-irradiated animals as an endpoin
t. The results have shown that DP and AMP act additively with G-CSF to enha
nce spleen colony formation and thus the erythroid repopulation of the sple
en. These findings indicate that the signaling pathways of G-CSF and drugs
elevating extracellular adenosine can interact at the level of primitive he
mopoietic stem cells. The enhancement of hemopoiesis-stimulating effects of
G-CSF by DP and AMP, which are low-priced and clinically available drags,
could improve the cost-effectiveness of the therapy with G-CSF.