J. Lopez-olguin et al., Structure-activity relationships of natural and synthetic neo-clerodane diterpenes from Teucrium against Colorado potato beetle larvae, PHYTOCHEM, 50(5), 1999, pp. 749-753
Treatment of potato leaf disks with ten neo-clerodane diterpenes isolated f
rom Teucrium and with ten of their synthetic derivatives, resulted in a sig
nificant antifeedant activity against Leptinotarsa decemlineata larvae in b
oth choice and no-choice assays for nine of the natural products and three
of the hemisynthetic compounds. Changes in the antifeedant activity were as
sociated with certain structural features of the compounds and some signifi
cant aspects of the structure-activity relationship are discussed. (C) 1999
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