Two bioactive mono-tetrahydrofuran acetogenins, annoglacins A and B, from Annona glabra

Two new bioactive mono-THF Annonaceous acetogenins, annoglacins A and B, ha ve been isolated from the fractionated ethanolic extracts of the leaves of Annona glabra, directing the fractionation with the brine shrimp lethality test (BST). Their structures were elucidated based on spectroscopic and che mical methods and the absolute stereochemistries were determined by the adv anced Mosher ester method. Annoglacins A and B were selectively 1000 and 10 ,000 times, respectively, more potent than adriamycin against the human bre ast carcinoma (MCF-7) and pancreatic carcinoma (PACA-2) cell lines in our p anel of six human solid tumor cell lines. (C) 1999 Elsevier Science Ltd. Al l rights reserved.