Phenolic aporphine-benzylisoquinoline alkaloids from Thalictrum faberi

From the roots of Thalictrum faberi, six new phenolic aporphine-benzylisoqu inoline alkaloids, 3-hydroxy-6 '-desmethyl-9-O-methylthalifaboramine (1), 3 -hydroxythalifaboramine (2), 6 '-desmethylthalifaboramine (3); 3,5 '-dihydr oxythalifaboramine (4), 5 '-hydroxythalifaboramine (5) and 3-hydroxy-6 '-de smethylthalifaboramine (6) were isolated. Their structures were established through the use of one- and two-dimensional NMR techniques. All of the tes ted alkaloids showed potent cytotoxic and antimalarial activities. (C) 1999 Elsevier Science Ltd. All rights reserved.