Search for new antihistaminic compounds by molecular connectivity

In this paper it is demonstrated that by adequate selection of topological descriptors we can make possible the prediction of different pharmacologica l properties, such as plasmatic concentration or sedative effect, within a group of antihistaminic drugs. Moreover, also demonstrated is the usefulnes s of molecular connectivity in the search of new active compounds. Examples of such compounds are 4-(1-buthylpenthyl)pyridine, N-(3-bromopropyl)-phtal imide and N-(3-chlorpropyl)-piperidin hydrochloride. All of them show antih istaminic activity values more than 30% higher than that of terfenadine, wh ich is used as the reference drug.