This work discusses the main clinical features of inflammatory bon el disea
se (IBD) and the methods to obtain an accurate diagnostic. Nuclear medicine
procedures are deeply analyzed, with special emphasis In those where clini
cal experience is larger and that are available for clinical practice in mo
st countries. In the opinion of the authors Tc-99m-HMPAO is the first choic
e agent, while In-111-oxine could be considered as the gold standard for ev
aluation of new agents. In the context of IBD, the WBC scintigraphy is usef
ul for its diagnosis (early and accurate) and the evaluation of disease ext
ension Cn hole bowel examination, without patient preparation and negligibl
e risk). The evaluation of disease severity deserves further experiences.