Radiation-induced graft polymerization is the key to develop high-performance functional materials for protein purification

We have described a preparation scheme for immobilizing polymer chains at a uniformly high density onto a microfiltration membrane. Highly efficient p rotein recovery was demonstrated by the results of the determination of bre akthrough and elution curves. The three requirements of high rare, high cap acity, and repeated use for the protein recovery were satisfied by ensuring the occurrence of convection, multilayer binding, and hydrophilization, re spectively. In addition, easy scale-up to fabrication of a membrane module was verified on a small scale. (C) 1999 Published by Elsevier Science Ltd, All rights reserved.