Impact of localized radiotherapy on blood immune cells counts and functionin humans

Authors
Belka, C Ottinger, H Kreuzfelder, E Weinmann, M Lindemann, M Lepple-Wienhues, A Budach, W Grosse-Wilde, H Bamberg, M
Citation
C. Belka et al., Impact of localized radiotherapy on blood immune cells counts and functionin humans, RADIOTH ONC, 50(2), 1999, pp. 199-204
Citations number
20
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Onconogenesis & Cancer Research
Journal title
RADIOTHERAPY AND ONCOLOGY
ISSN journal
01678140 → ACNP
Volume
50
Issue
2
Year of publication
1999
Pages
199 - 204
Database
ISI
SICI code
0167-8140(199902)50:2<199:IOLROB>2.0.ZU;2-W
Abstract
Immune cells subsets were prospectively analyzed after localized radiothera py (LRT). LRT reduced the levels of all lymphocyte subsets, with B-cells an d naive T-cells being most sensitive. Lymphocyte function was suppressed, b ut still within the normal range. Rapid recovery of cytotoxic T-cells/natur al killer cells after LRT and the functional suppression within normal leve ls explains the low incidence of infections after LRT. (C) 1999 Elsevier Sc ience Ireland Ltd. All rights reserved.