The effects of intraperitoneal piroxicam and low molecular weight heparin in prevention of adhesion reformation in rat uterine horn

Our objective was to determine the effectiveness of intraperitoneal single dose piroxicam and low molecular weight heparin (LMWH) on prevention of adh esion reformation in the rat uterine horn. This study was carried out in th e Surgical Research Laboratory, at Erciyes University. A standard lesion wa s created by unipolar electrocautery in 72 uterine horns of 36 female Wista r-Albino rats. After 2 weeks, adhesion formation scores were determined and adhesiolysis was performed in the second-look laparotomy. Animals were the n randomly assigned into three groups. Each group contained 12 animals: gro up 1 was the control group where no adjuvant was given; in group 2, 1 mi 50 U Axa IC/ml solution LMWH was applied to the horns postoperatively, and in group 3, 1 ml 2 mg/ml piroxicam solution was applied to the horns after ad hesiolysis. Two weeks later the rats were killed and adhesion reformation w as evaluated. The number of hems with adhesion formation and the cumulative scores were not significantly different among the three groups in the seco nd-look laparotomies, but after third-look laparotomies, the number of horn s with adhesion reformation, after calculating the extent, severity and tot al scores of adhesion reformation, was found to be significantly less in LM WH and piroxicam groups than in the control group. Also, the effectiveness of piroxicam was significantly greater in all scores of adhesion reformatio n than LMWH was. In conclusion, both LMWH and piroxicam doses reduce adhesi on reformation in the rat uterine horn, but the effectiveness of piroxicam is significantly greater than that of LMWH.