A. Nozari et al., Maximisation of cerebral blood flow during experimental cardiopulmonary resuscitation does not ameliorate post-resuscitation hypoperfusion, RESUSCITAT, 40(1), 1999, pp. 27-35
Continuous intra-aortic balloon occlusion has been reported to improve cere
bral blood flow during cardiopulmonary resuscitation (CPR) but not to ameli
orate the impaired blood recirculation occurring after restoration of spont
aneous circulation (ROSC). Volume expansion with hypertonic solutions may i
mprove recovery of brain function by enhancing post-resuscitation cerebral
blood flow. We hypothesised that the combination of these treatments with o
pen-chest CPR would improve cerebral blood flow during CPR, and attenuate p
ost-resuscitation flow disturbances. In 32 anaesthetised piglets, catheters
were placed for haemodynamic and blood gas monitoring. Open-chest CPR was
initiated after 9 min of ventricular fibrillation. The piglets were treated
either with 3 ml kg(-1) hypertonic saline and dextran (HSD) (n = 10), HSD
and balloon occlusion (n = 10) or with normal saline (n = 12). After 7 min
of CPR, internal defibrillatory shocks were administered to restore spontan
eous circulation. Haemodynamic variables, continuous cerebral cortical bloo
d flow, cerebral tissue pH and pCO2 and blood gas parameters were measured
during CPR and up to 210 min after ROSC. Higher cerebral perfusion pressure
was found in the balloon-HSD group during CPR. This group exhibited less a
rterial hypertension immediately after ROSC compared with the other groups.
Thereafter, a fairly rapid decrease of the perfusion pressures was observe
d in all groups reaching a minimum level approximately 30 min after ROSC. C
erebral cortical blood flow was significantly higher and cerebral oxygen ex
traction ratio significantly lower in the balloon-HSD group during CPR, but
not after ROSC. In conclusion, a combination of intra-aortic balloon occlu
sion and HSD administration improves cerebral blood flow and brain oxygen s
upply during experimental open-chest CPR. In contrast, cerebral blood flow
after ROSC was not shown to be influenced by this treatment. (C) 1999 Elsev
ier Science Ireland Ltd. All rights reserved.