A new case of NSAID-induced infertility

A 38-year-old woman on piroxicam for hip osteoarthritis secondary to hip dy splasia developed secondary sterility. Ova collected for in vitro fertiliza tion were immature and failed to fertilize. A further attempt done after pi roxicam discontinuation produced seven mature ova that fertilized, allowing embryo implantation. Nonsteroidal antiinflammatory drugs may induce infert ility by reducing the production of prostaglandins, most notably via inhibi tion of the enzyme cyclooxygenase 2. The impact of nonsteroidal antiinflamm atory drug therapy on reproductive function needs to be evaluated.