INFLUENCE OF THE CHROMATOGRAPHIC CAPACITY FACTOR (LOG K') AS AN INDEXOF LIPOPHILICITY IN THE ANTIBACTERIAL ACTIVITY OF A SERIES OF 6-FLUOROQUINOLONES - RELATIONSHIP BETWEEN PHYSICOCHEMICAL AND STRUCTURAL-PROPERTIES AND THEIR HYDROPHOBICITY

The aim of this study was to establish the influence of lipophilicity on the antibacterial activity (log 1/MIC(50)) of 22 fluoroquinolones a nd to assess the influence of their electronic, steric and topological properties on their hydrophobicity. The lipophilicity of the compound s, expressed as the chromatographic capacity factor (log k'), was dete rmined by ion-pair reversed-phase HPLC. On the basis of the mathematic al models developed, an attempt was made to confirm the mechanism of i nteraction of the quinolones with DNA-gyrase proposed previously.