The immunotolerance role of HLA-G

Citation
N. Rouas-freiss et al., The immunotolerance role of HLA-G, SEM CANC B, 9(1), 1999, pp. 3-12
Citations number
40
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
SEMINARS IN CANCER BIOLOGY
ISSN journal
1044579X → ACNP
Volume
9
Issue
1
Year of publication
1999
Pages
3 - 12
Database
ISI
SICI code
1044-579X(199902)9:1<3:TIROH>2.0.ZU;2-Y
Abstract
HLA-G is a non-classical Il MHC class I molecule involved in immune toleran ce. We present our results concerning the effects of HLA-G on the cellular immune response, where it impairs both NK and T cell functions. We describe the NK inhibitory properties of HLA-G ex vivo, demonstrating its role in m aterno-fetal tolerance, which is supported by our in vitro studies using,me mbrane-bound HLA-G1- and HLA-G2-transfected cells and a full-length soluble HLA-G molecule. We also report how HLA-G interacts at the T cell level, he re exemplified by its inhibitory effect on both T cell allogeneic prolifera tive and Ag-specific CTL responses.