Duplex scanning exploration of the ophthalmic artery for the detection of the hemodynamically significant ICA stenosis

Background and Purpose-The North American and the European Carotid Endarter ectomy Trials demonstrated a significant benefit of surgery in preventing s troke for patients with symptomatic hemodynamically significant internal ca rotid artery (ICA) stenosis. Because the 3 angiographic methods of measurin g carotid stenosis provide discrepant results, the indication for surgery d epends on the method used for the evaluation of the angiogram. The goal of this study was to verify whether color duplex scanning of the ophthalmic ar tery alone might be reliable for detection of the extracranial hemodynamica lly significant ICA stenosis. Methods-Three groups of patients (351 total patients) with transient ischem ic attack or minor stroke referred for possible carotid endarterectomy were examined by means of color duplex scanning of the ICA, transcranial Dopple r, color duplex scanning of the ophthalmic artery, and angiography of the I CA. Results-In the first group (n = 31) the comparison of findings from each me thod and the direct measurement of the residual lumen of plaque removed "en bloc" showed that the findings of the ophthalmic artery color duplex scann ing, subdivided into 5 categories-NP (normal positive), LP (low positive), NF (no flow), REV (reverse flow), PP (pathological positive)-were associate d with the best overall agreement (96.7%). The accuracy of the various cate gories of the ophthalmic artery color duplex scanning signals was studied i n the second group of patients (n = 200). The results pointed out that all but low positive categories were associated with high diagnostic accuracy. Finally, the results obtained in the third group (n = 120) showed that a si gnificant increase in the specificity of the low positive signal could be o btained by processing this signal in terms of pulsatility index and of tran smission of pulsatility index. Conclusions-Our results suggest that the diagnostic capacity of color duple x scanning for the detection of ICA critical stenosis can be appropriately increased if it is performed also at the level of the ophthalmic artery and if the Doppler signals are processed on the basis of criteria we applied.