2 '-deoxyribo-PNAs: A structurally novel class of polyamide nucleic acids with good RNA and DNA binding affinity

Authors
von Matt, P De Mesmaeker, A Pieles, U Zurcher, W Altmann, KH
Citation
P. Von Matt et al., 2 '-deoxyribo-PNAs: A structurally novel class of polyamide nucleic acids with good RNA and DNA binding affinity, TETRAHEDR L, 40(15), 1999, pp. 2899-2902
Citations number
27
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
15
Year of publication
1999
Pages
2899 - 2902
Database
ISI
SICI code
0040-4039(19990409)40:15<2899:2'ASNC>2.0.ZU;2-Q
Abstract
2'-Deoxyribo polyamide nucleic acids (2'-deoxyribo-PNAs) 3 are a new class of DNA analogs with a 2',3'-dideoxyribose-polyamide backbone structure. 2'- Deoxyribo-PNAs as well as chimeric oligonucleotide analogs with a mixed DNA / 2'-deoxyribo-PNA structure bind to single stranded complementary nucleic acids with similar affinities as natural DNA. (C) 1999 Elsevier Science Lt d. All rights reserved.