Novel sesquiterpene esters with alkaloid and monoterpene and related compounds from Tripterygium hypoglaucum: A new class of potent anti-HIV agents

Authors
Duan, HQ Takaishi, Y Bando, M Kido, M Imakura, Y Lee, KH
Citation
Hq. Duan et al., Novel sesquiterpene esters with alkaloid and monoterpene and related compounds from Tripterygium hypoglaucum: A new class of potent anti-HIV agents, TETRAHEDR L, 40(15), 1999, pp. 2969-2972
Citations number
10
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
15
Year of publication
1999
Pages
2969 - 2972
Database
ISI
SICI code
0040-4039(19990409)40:15<2969:NSEWAA>2.0.ZU;2-6
Abstract
Two new sesquiterpene polyol esters (triptonine A and B) with alkaloid and monoterpene were isolated from Tripterygium hypoglaucum (Levl.) Hutch. Thei r structures were elucidated by spectroscopic means and X-ray analysis. Tri ptonine A (1) and hypoglaunine B-3) (4) demonstrated potent anti-HIV activi ty with EC50 values of 2.54 and 0.13 mu g/ml and therapeutic index values o f 39.4 and >1000, respectively. (C) 1999 Elsevier Science Ltd. All rights r eserved.