An efficient copper-catalyzed coupling of aryl halides with imidazoles

Authors
Kiyomori, A Marcoux, JF Buchwald, SL
Citation
A. Kiyomori et al., An efficient copper-catalyzed coupling of aryl halides with imidazoles, TETRAHEDR L, 40(14), 1999, pp. 2657-2660
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
14
Year of publication
1999
Pages
2657 - 2660
Database
ISI
SICI code
0040-4039(19990402)40:14<2657:AECCOA>2.0.ZU;2-U
Abstract
Copper-catalyzed N-arylation of imidazoles can be accomplished using (CuOTf )(2). benzene as a copper source and Cs2CO3 as a base in xylenes at 110-125 degrees C. Addition of l,l0-phenanthroline (phen) and trans, trans-dibenzy lideneacetone (dba) was crucial to the success of the process. The products , N-arylimidazoles, were isolated in high yields. (C) 1999 Elsevier Science Ltd. All rights reserved.