The influence of geminal disubstitution on efficiencies of 4-exo-trig radical cyclizations.

Authors
Jung, ME Marquez, R Houk, KN
Citation
Me. Jung et al., The influence of geminal disubstitution on efficiencies of 4-exo-trig radical cyclizations., TETRAHEDR L, 40(14), 1999, pp. 2661-2664
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
14
Year of publication
1999
Pages
2661 - 2664
Database
ISI
SICI code
0040-4039(19990402)40:14<2661:TIOGDO>2.0.ZU;2-L
Abstract
The competition between tributyltin hydride-induced cyclization and reducti on of a series of 6-bromo-2-hexenoates was explored computationally. Differ ent methods show that modification of the gem-substituents is not as crucia l for cyclization as once thought. (C) 1999 Elsevier Science Ltd. All right s reserved.