A new "traceless" solid-phase synthesis strategy: Synthesis of a benzimidazole library

A new strategy to achieve "traceless" solid-phase synthesis has been develo ped. Using this strategy, a "traceless" benzimidazole library with diversit y on the benzene moiety was synthesized efficiently in high yield with high purity. During the final step of this new synthetic sequence, cleavage and cyclic nucleus elaboration take place by a series of substitution and elim ination reactions on the solid phase followed by release to the solution ph ase. (C) 1999 Elsevier Science Ltd. All rights reserved.