Stereoselective reductive amination of chiral N,N-Dibenzylamino ketones

Authors
Reetz, MT Schmitz, A
Citation
Mt. Reetz et A. Schmitz, Stereoselective reductive amination of chiral N,N-Dibenzylamino ketones, TETRAHEDR L, 40(14), 1999, pp. 2741-2742
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
14
Year of publication
1999
Pages
2741 - 2742
Database
ISI
SICI code
0040-4039(19990402)40:14<2741:SRAOCN>2.0.ZU;2-V
Abstract
N,N-Dibenzylamino ketones of the type Bn2N(R)CHC(O)CH3, prepared in enantio merically pure form from alpha-amino acids, undergo stereoselective reducti ve amination using PhCH2NH2/NaCNBH3 or NH4OAc/NaCNBH3 with formation of dia stereo- and enantiomerically pure vicinal diamines Bn2N(R)CHCH(NHCH2Ph)CH3 or Bn2N(R)CHCH(NH2)CH3, respectively. (C) 1999 Elsevier Science Ltd. All ri ghts reserved.